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dkoukou
Senior Forum-Runner
Greece
591 Δημοσιεύσεις |
 Δημοσιεύθηκε - 28/01/2013 : 14:13:19
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Στα γρηγορα...
J Sports Med Phys Fitness. 2012 Apr;52(2):170-4.
Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity.
Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B.
Source
Islamic Azad University-Ardabil branch, Ardabil, Iran.
Abstract
AIM:
The aim of this study was to evaluate effect of 10-day methylsulfonylmethane (MSM) supplementation on exercise-induced muscle damage.
METHODS:
Eighteen healthy, non-smoking, active young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (M) (N.=9) and placebo (P) (N.=9). Subjects consumed daily either placebo (200 mL water) or MSM supplement (50 mg/kg MSM in 200 mL water) for 10 days. Afterward, participants ran 14 km. Blood samples were taken before supplementation, before exercise, immediately, 30 min, 2, 24 and 48 h after exercise.
RESULTS:
CK and bilirubin significantly increased in P group 24 h after exercise compared to M group (P=0.041 and P=0.002, respectively). TAC increased immediately post, 30 min, 2 and 24 h after exercise just in M group (P<0.05). TAC showed significant increase in M group 2 and 24 h after exercise compared to P group (P=0.014 and P=0.033, respectively).
CONCLUSION:
It seems that 10-day supplementation with MSM has allowed to decrease muscle damage via effect on antioxidant capacity.
PMID: 22525653 [PubMed - indexed for MEDLINE]
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Osteoarthritis Cartilage. 2008 Nov;16(11):1277-88. doi: 10.1016/j.joca.2008.03.002. Epub 2008 Apr 15.
Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis.
Brien S, Prescott P, Bashir N, Lewith H, Lewith G.
Source
Department of Primary Care, University of Southampton, UK. sbb@soton.ac.uk
Abstract
OBJECTIVE:
Conventional treatment of osteoarthritis (OA) with non-steroidal anti-inflammatory drugs is associated with serious gastrointestinal side effects and in view of the recent withdrawal of some cyclo-oxygenase-2 inhibitors, identifying safer alternative treatment options is needed. The objective of this systematic review is to evaluate the existing evidence from randomised controlled trials of two chemically related nutritional supplements, dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of OA to determine their efficacy and safety profile.
METHODS:
The electronic databases [Cochrane Library, Medline, Embase, Amed, Cinahl and NeLH (1950 to November 2007)] were searched. The search strategy combined terms: osteoarthritis, degenerative joint disorder, dimethyl sulfoxide, DMSO, methylsulfonylmethane, MSM, clinical trial; double-blind, single blind, RCT, placebo, randomized, comparative study, evaluation study, control. Inclusion and exclusion criteria were applied. Data were extracted and quality was assessed using the JADAD scale.
RESULTS:
Six studies were included [evaluating a total of 681 patients with OA of the knee for DMSO (N=297 on active treatment); 168 patients for MSM (N=52 on active treatment)]. Two of the four DMSO trials, and both MSM trials reported significant improvement in pain outcomes in the treatment group compared to comparator treatments, however, methodological issues and concerns over optimal dosage and treatment period, were highlighted.
CONCLUSION:
No definitive conclusion can currently be drawn for either supplement. The findings from all the DMSO studies need to be viewed with caution because of poor methodology including; possible unblinding, and questionable treatment duration and dose. The data from the more rigorous MSM trials provide positive but not definitive evidence that MSM is superior to placebo in the treatment of mild to moderate OA of the knee. Further studies are now required to identify both the optimum dosage and longer-term safety of MSM and DMSO, and definitive efficacy trials.
PMID: 18417375 [PubMed - indexed for MEDLINE]
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Am J Epidemiol. 2012 Dec 1;176(11):1002-13. doi: 10.1093/aje/kws186. Epub 2012 Nov 8.
Association between use of specialty dietary supplements and C-reactive protein concentrations.
Kantor ED, Lampe JW, Vaughan TL, Peters U, Rehm CD, White E.
Source
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. ekantor@fhcrc.org
Abstract
Laboratory evidence suggests that certain specialty dietary supplements have antiinflammatory properties, though evidence in humans remains limited. Data on a nationally representative sample of 9,947 adults from the 1999-2004 cycles of the National Health and Nutrition Examination Survey were used to assess the associations between specialty supplement use and inflammation, as measured by serum high-sensitivity C-reactive protein (hs-CRP) concentration. Using survey-weighted multivariate linear regression, significant reductions in hs-CRP concentrations were associated with regular use of glucosamine (17%, 95% confidence interval (CI): 7, 26), chondroitin (22%, 95% CI: 8, 33), and fish oil (16%, 95% CI: 0.3, 29). No associations were observed between hs-CRP concentration and regular use of supplements containing methylsulfonylmethane, garlic, ginkgo biloba, saw palmetto, or pycnogenol. These results suggest that glucosamine and chondroitin supplements are associated with reduced inflammation in humans and provide further evidence to support an inverse association between use of fish oil supplements and inflammation. It is important to further investigate the potential antiinflammatory role of these supplements, as there is a need to identify safe and effective ways to reduce inflammation and the burden of inflammation-related diseases such as cancer and cardiovascular disease.
PMID: 23139249 [PubMed - in process]
Με λιγα λογια, εχουμε μελετες (2 συνολικα) απο το Ιραν που λενε οτι εχει σημαντικη αντιφλεγμονωδη δραση ιδιως μετα απο ασκηση και μετα-αναλυσεις μελετων απο Αγγλια και Αμερικη οι οποιες λενε οτι πιθανως εχει δραση κατα της οστεοαρθριτιδας γονατος (η πρωτη) και καμμια μετρησιμη αντιφλεγμονωδη δραση (η δευτερη).
Θα ημουν πολυ προσεκτικος (και) με αυτο το "θαυματουργο" συμπληρωμα...
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"...κάποτε, με τον πατέρα σου, είχαμε σε δωδεκαρι πέρασμα 6'06" στο 2ο χιλιόμετρο. Θυμάσαι ρε; Τότε είμασταν καλοί..." |
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MSM
